WebDec 7, 2024 · A particularly exciting paper, recently published in Lancet Respiratory Medicine (Richeldi et al. 2024), described the recently successful Phase II clinical trial, PRAISE, which was a randomised, double-blind, placebo-controlled trial of the anti-CCN2 antibody FG-3019 (pamrevlumab) in idiopathic pulmonary fibrosis (IPF) … WebMonoclonal Antibody for studying CTGF. Cited in 36 publications. Validated for Western Blotting, Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, CTGF (D8Z8U) Rabbit Monoclonal Antibody (CST #86641) is ready to ship. ... Antibody Dilution Buffer (1X PBS / 1% BSA / 0.3% Triton X-100): To prepare 10 …
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WebAug 24, 2024 · CTGF, a protein localized in the extracellular matrix, is a driver of fibrotic tissue remodeling as a consequence of an aberrant wound healing process. WebMonoclonal Antibody for studying CTGF. Cited in 36 publications. Validated for Western Blotting, Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, CTGF (D8Z8U) Rabbit … eases guidelines nursing home
Pamrevlumab Trials FibroGen
WebJul 22, 2024 · Pamrevlumab, an anti-CTGF human monoclonal antibody, is advancing towards Phase 3 clinical development for the treatment of idiopathic pulmonary fibrosis (IPF) and pancreatic cancer, and is currently in a Phase 2 trial for Duchenne muscular dystrophy (DMD). FibroGen is also developing a biosynthetic cornea in China. WebInhibiting CTGF with antisense oligonucleotides, small interfering RNA, or neutralizing antibodies has been reported to reduce fibrosis in experimental models of kidney disease (Lee et al., 2015). The results of a phase I trial of FG-3019, an anti-CTGF antibody, demonstrated that this agent reduced albuminuria in patients with diabetic nephropathy. WebApr 11, 2024 · Nevertheless, clinical observations have shown that CTGF expression in the sera and fibrotic liver tissues of CHB patients is upregulated. A strong correlation between CTGF with liver fibrosis has also been reported . HBX can induce CTGF expression and secretion in hepatocytes to stimulate HSC activation . Multiple regulatory mechanisms ... ease sewing definition