Cytotoxicities
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (Bitis arietans) or brown recluse spider (Loxosceles reclusa). See more Treating cells with the cytotoxic compound can result in a variety of cell fates. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. The cells can stop actively growing … See more Some chemotherapies contain cytotoxic drugs, whose purpose is interfering with the cell division. These drugs cannot distinguish between normal and malignant cells, but they … See more Antibody-dependent cell-mediated cytotoxicity (ADCC) describes the cell-killing ability of certain lymphocytes, which requires the target cell being marked by an antibody. Lymphocyte-mediated cytotoxicity, on the other hand, does not have to be … See more Cytotoxicity assays are widely used by the pharmaceutical industry to screen for cytotoxicity in compound libraries. Researchers can either look for cytotoxic compounds, if they … See more A highly important topic is the prediction of cytotoxicity of chemical compounds based on previous measurements, i.e. in-silico testing. For this purpose many QSAR and virtual screening methods have been suggested. An independent comparison of these methods has … See more • Antireticular Cytotoxic Serum • Host-pathogen interface • Membrane vesicle trafficking See more • Cytotoxins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebAbstract. Commercially exploitable compounds are being produced using modern biotechnology for use as food additives, chemotherapeutic agents, and pesticides. Traditionally, animal testing has always played an important role in the safety evaluation of such agents. However, financial and ethical considerations, together with an increased ...
Cytotoxicities
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WebGlutathione (GSH) plays a role in many toxicologically important metabolic processes. It was previously established that L-buthionine S,R-sulphoximine (BSO), a … WebGlioblastoma multiforme is the most common and most aggressive human brain cancer. GBM treatment is still a challenge because many drugs are not able to cross the blood-brain barrier, in addition to the increasing resistance to currently available chemotherapy. New therapeutic alternatives are emerg …
WebSep 12, 2024 · Cytotoxicities of the quinolizidine alkaloid (–)-cytisine and 19 of its derivatives with substituents in the 3-, 9-, and 11-positions were assessed against A431 (epidermal carcinoma), A375 (melanoma), and HCT 116 (colorectal carcinoma) tumor cell lines using the MTT assay (etoposide reference drug). Practically all synthesized … WebCytotoxicity definition, cell destruction caused by a cytotoxic substance. See more.
WebMay 25, 2024 · Their cytotoxicities were tested against Ca9-22, HSC-2, HSC-3, and HSC-4 human oral squamous cell carcinoma as tumour cell lines and HGF, HPC, and HPLF human normal oral cells as non tumour cell ...
WebCell viability and cell density of the thermal-injured keratinocytes treated with HA (600, 1070, and 1500 kDa) were increased significantly compared with that of model control ( P < …
WebCytotoxic evaluation showed that norditerpenoid dilactones bearing 3β-OH and 1,2-β-epoxide or 2,3-β-epoxide (1,2-β-epoxide or alkenyl 3β-OH) displayed promising … heloise gosselinWebFeb 2, 2024 · In our previous work, eight anti-inflammatory and anti-cancer triterpenes were reported from the sub-Fr. C2, C3, and C5. 5b Further study showed that the remaining sub-Fr. C1 and C6 displayed significant cytotoxicities against lung cancer A-549 and hepatocellular carcinoma SMMC7721 cancer cells with inhibition rates exceeding 96%, … heloise arnisolleWebAggregation kinetics, aggregates and cytotoxicities of wild-type, Flemish and Dutch amyloid-β mixtures are explored. The interaction could strengthen or inhibit cytotoxicity of Aβ42/Aβ40 mixture. The... heloise billonnetWebAug 5, 2013 · Investigating changes in the number and cytotoxicity of CD3+CD56+ T lymphocytes in the peripheral blood of acute leukemia (AL) patients suggested that cellular immunity may respond to AML and ALL, but that lymphocyte cytotoxicities remains impaired. Recent reports have highlighted the role of cellular immunity in anti-tumor … heloise arphiWebCytotoxicity Assays. Cytotoxicity is the degree to which a substance can cause damage to a cell. A substance or process that causes cell damage or death is referred to as cytotoxic, "cyto" meaning cell and "toxic" meaning poison. Cells exposed to cytotoxic compounds may undergo necrosis (uncontrolled cell death), apoptosis (programmed cell ... heloise blainWebGlutathione (GSH) plays a role in many toxicologically important metabolic processes. It was previously established that L-buthionine S,R-sulphoximine (BSO), a specific inhibitor of γ-glutamylcysteine synthetase, reduces the GSH content more heloise ellzeyWebApr 11, 2024 · Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent enzymes. Oxythiamine has been used to validate thiamine utilization as an anti-malarial … heloise billotte