WebDrug Interaction Studies. Simvastatin acid is a substrate of the transport protein OATP1B1. Concomitant administration of inhibitors of the transport protein OATP1B1 and/or CYP3A4 may lead to increased exposure of simvastatin acid. ... Table 4 displays the effect of coadministered drugs or grapefruit juice on simvastatin systemic exposure [see ... WebFor example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine.
Grapefruit and statins: Interaction, side effects, and more
WebJun 11, 2024 · Drinking grapefruit juice while taking atorvastatin (Lipitor) or other "statins" might increase the effects and side effects of these medications. Grapefruit might interact with some "statins" including lovastatin ( Mevacor ), simvastatin ( Zocor ), and atorvastatin (Lipitor). WebDec 26, 2024 · Grapefruit juice inhibits this enzyme. When the enzyme can’t process the medication as efficiently, the drug levels can build up, causing worsened or more … rbl interest rate
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WebBackground: Simvastatin is a cholesterol-lowering agent that is metabolized through CYP3A4. We studied the effect of grapefruit juice on the pharmacokinetics of orally … WebJul 28, 2024 · Doctors warn against consuming Grapefruit juice if you take certain types of medication, such as statins, which are metabolized by the CYP3A4 enzyme. Grapefruit juice inhibits this enzyme so the liver produces less of it, and this affects the action of those drugs – they will be less effective. This is known as a drug interaction. Grapefruit contains a chemical that can interfere with your body’s ability to break down or metabolize certain statin medications. When … See more The introduction of statin medications has helped patients: 1. Lower LDL (Low-density lipoprotein cholesterol or “bad” cholesterol). 2. … See more Only certain statin medications interact negatively with grapefruit. This is an issue only for lovastatin (Mevacor) and simvastatin (Zocor, or Vytorin) and typically is only … See more sims 4 clothing mods pjs