WebStructural and biochemical studies showing that abacavir binds non-covalently to the floor of the peptide binding groove of HLA-B*5701 with exquisite specificity to alter the self … WebJun 2, 2016 · Altered peptide repertoire model shares some similarities with p-i concept in that a drug-pHLA complex plays an important role . As discussed later, it can be regarded …
Abacavir and the altered peptide repertoire model: clinical ... - CORE
WebMar 31, 2024 · Bila obat dapat memodifikasi molekul HLA, akan terbentuk peptida yang berbeda (altered peptide model). Walaupun demikian, perubahan peptida tidak diperlukan untuk membuat peptide-HLA complex bersifat imunogenik; bila obat berikatan dengan HLA, maka gabungan dari altered HLA dan peptida normal dapat bersifat imunogenik dan … WebJul 19, 2016 · The 'altered-peptide' model needs to account for the main function of thymic selection, which is to ensure the deletion of T cells bearing TCRs with strong self-reactivity. david whiting rpc
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WebThe altered peptide model of positive selection states that positive and negative selection: a. are mediated by different peptides. a. are mediated by different peptides . 2. As double … WebMar 1, 1995 · This led to a serendipitous primary reactivity to Ser69 peptide, an altered peptide ligand of the Hbd (64-76) epitope of the parent clone. Two Ser69-reactive T cell populations were identified. WebMay 21, 2024 · In this issue of the JCI, Cardone et al. have developed an HLA-B*57:01–transgenic mouse model and demonstrated that CD4 + T cells play a key role in … david whiting lawyer