Tnbc ferroptosis
Webb11 apr. 2024 · The article reports on a study investigating the role of nerve growth factor (NGF) and its receptor, tropomyosin receptor kinase A (TrkA), in triple-negative breast cancer (TNBC). The authors found that TNBC-derived MDA-MB-231 and MDA-MB-453 cells express TrkA and release biologically active NGF, which positively affects the migration, … Webb25 mars 2024 · Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes.
Tnbc ferroptosis
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Webb20 feb. 2024 · Ferroptosis is a non-apoptotic form of cell death linked to the accumulation of reactive hydroperoxides generated by oxidation of polyunsaturated fatty acids (PUFAs) in membrane phospholipids. The therapeutic potential of promoting ferroptosis by enriching PUFAs in cancer cells is unknown. Webb2 juni 2024 · Development and Verification of a Prognostic Ferroptosis-Related Gene Model in Triple-Negative Breast Cancer Development and Verification of a Prognostic …
Webb6 feb. 2024 · In multiple TNBC cell lines and primary patient TNBC cells, MS8815 effectively suppresses cell growth. It induced nearly complete degradation of EZH2 and exhibited the most robust degradation at 0.3 μM. Webb11 apr. 2024 · Patients with TNBC have a low likelihood of benefiting from traditional therapy based on hormones or ... Tai WC-S, et al. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine ...
Webb9 dec. 2024 · Purpose Triple-negative breast cancer (TNBC) is an aggressive tumor with poor prognosis, it has higher recurrence and metastatic rates than other breast cancer subtypes. This study aims to investigate biomarkers and potential targets for TNBC related to ferroptosis through data mining and bioinformatics analysis. Webb8 apr. 2024 · The overexpression of α v β 3 and α v β 5 integrins and elevated levels of NRP-1 in TNBC are exploited for iRGD to emerge as a potential candidate for anticipating effective therapeutic outcomes. To evaluate the effect of iRGD in breast cancer, the peptide was co-administered with cancer therapeutics as a free drug or nanotherapeutic or in …
WebbConsequently, THEM6 loss in CRPC cells significantly alters ER function, reducing de novo sterol biosynthesis and preventing lipid-mediated activation of ATF4. Finally, we demonstrate that high...
Webb2 apr. 2024 · Rigid Shell Decorated Nanodevice with Fe/H 2 O 2 Supply and Glutathione Depletion Capabilities for Potentiated Ferroptosis and Synergized Immunotherapy @article{2024RigidSD, title={Rigid Shell Decorated Nanodevice with Fe/H 2 O 2 Supply and Glutathione Depletion Capabilities for Potentiated Ferroptosis and Synergized … massachusetts state board of nursing renewalWebb20 maj 2024 · The term ferroptosis refers to a peculiar type of programmed cell death (PCD) mainly characterized by extensive iron-dependent lipid peroxidation. Recently, … hydrangea medicineWebbRationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition of cystine-glutamate antiporter system X C- because of the impaired uptake of cystine. However, the outcome following the accumulation of endogenous glutamate in lung adenocarcinoma (LUAD) has not yet been determined. hydrangea magical green cloudWebb12 apr. 2024 · Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor … massachusetts state board of nursing contactWebb15 jan. 2024 · Triple-negative breast cancer (TNBC) is a subtype of breast cancer without a targeted form of therapy. Unfortunately, up to 70% of patients with TNBC develop resistance to treatment. A known contributor to chemoresistance is dysfunctional mitochondrial apoptosis signaling. massachusetts state board of nursing licenseWebb21 aug. 2024 · This study identified potent combination therapies for TNBC and unveiled ferroptosis as a promising therapeutic strategy. INTRODUCTION Targeted therapy … massachusetts state building codeWebbFerroptosis is an iron-dependent programmed cell death. Long non-coding RNAs (lncRNAs) emerge as a critical role in regulating cancer progression. Objective: This study aimed to identify molecular regulation of ferroptosis-related lncRNAs (FRLs) in ccRCC. hydrangea missouri botanical